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MIF demonstrates chemokine-like operate and was recognized like a ligand of both equally CXCR2 and CXCR4. Binding of MIF to these receptors improves monocyte recruitment and leukocyte chemotaxis (Figure 1). In human chondrosarcoma cells, this recruitment is mediated by Gαi proteins and PI3K in T click here mobile adhesion as a result of upregulati
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